
Research
Opus Biological is committed to providing only ethical and research-driven therapy for the treatment you require.
Research underpins every decision we make and forms a crucial component of our everyday practice.
Below you will find a list of research articles that reinforce the work we carry out at Opus, from successful cases of PRP injections to clinical trials.

References
Platelet Rich Plasma
- Chen, P., Huang, L., Ma, Y., Zhang, D., Zhang, X., Zhou, J., . . . Wang, Q. (2019). Intra-articular platelet-rich plasma injection for knee osteoarthritis: a summary of meta-analyses. J Orthop Surg Res, 14(1), 385.
- Dai, W. L., Zhou, A. G., Zhang, H., & Zhang, J. (2017). Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Meta-analysis of Randomized Controlled Trials. Arthroscopy, 33(3), 659-670.e651.
- Everts, P., Onishi, K., Jayaram, P., Lana, J. F., & Mautner, K. (2020). Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020. Int J Mol Sci, 21(20).
- Shen, L., Yuan, T., Chen, S., Xie, X., & Zhang, C. (2017). The temporal effect of platelet-rich plasma on pain and physical function in the treatment of knee osteoarthritis: systematic review and meta-analysis of randomized controlled trials. J Orthop Surg Res, 12(1), 16.
- Southworth, T. M., Naveen, N. B., Tauro, T. M., Leong, N. L., & Cole, B. J. (2019). The Use of Platelet-Rich Plasma in Symptomatic Knee Osteoarthritis. J Knee Surg, 32(1), 37-45.
Mesenchymal Stem Cell Therapy
- Freitag, J., Bates, D., Wickham, J., Shah, K., Huguenin, L., Tenen, A., . . . Boyd, R. (2019). Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial. Regen Med, 14(3), 213-230.
- Harrell, C. R., Markovic, B. S., Fellabaum, C., Arsenijevic, A., & Volarevic, V. (2019). Mesenchymal stem cell-based therapy of osteoarthritis: Current knowledge and future perspectives. Biomed Pharmacother, 109, 2318-2326.
- Kim, Y. G., Choi, J., & Kim, K. (2020). Mesenchymal Stem Cell-Derived Exosomes for Effective Cartilage Tissue Repair and Treatment of Osteoarthritis. Biotechnol J, 15(12), e2000082.
- Lee, W. S., Kim, H. J., Kim, K. I., Kim, G. B., & Jin, W. (2019). Intra-Articular Injection of Autologous Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Knee Osteoarthritis: A Phase IIb, Randomized, Placebo-Controlled Clinical Trial. Stem Cells Transl Med, 8(6), 504-511.
- Zhang, J., Rong, Y., Luo, C., & Cui, W. (2020). Bone marrow mesenchymal stem cell-derived exosomes prevent osteoarthritis by regulating synovial macrophage polarization. Aging (Albany NY), 12(24), 25138-25152.
Osteopathy
- Bill, A. S., Dubois, J., Pasquier, J., Burnand, B., & Rodondi, P. Y. (2020). Osteopathy in the French-speaking part of Switzerland: Practitioners’ profile and scope of back pain management. PLoS One, 15(5), e0232607.
- Cerritelli, F., Lacorte, E., Ruffini, N., & Vanacore, N. (2017). Osteopathy for primary headache patients: a systematic review. J Pain Res, 10, 601-611.
- Dal Farra, F., Risio, R. G., Vismara, L., & Bergna, A. (2021). Effectiveness of osteopathic interventions in chronic non-specific low back pain: A systematic review and meta-analysis. Complement Ther Med, 56, 102616.
- de Oliveira Meirelles, F., de Oliveira Muniz Cunha, J. C., & da Silva, E. B. (2020). Osteopathic manipulation treatment versus therapeutic exercises in patients with chronic nonspecific low back pain: A randomized, controlled and double-blind study. J Back Musculoskelet Rehabil, 33(3), 367-377.
- Groisman, S., Malysz, T., de Souza da Silva, L., Rocha Ribeiro Sanches, T., Camargo Bragante, K., Locatelli, F., . . . Jotz, G. P. (2020). Osteopathic manipulative treatment combined with exercise improves pain and disability in individuals with non-specific chronic neck pain: A pragmatic randomized controlled trial. J Bodyw Mov Ther, 24(2), 189-195.
Performance Psychology
- Brown, D. J., & Fletcher, D. (2017). Effects of Psychological and Psychosocial Interventions on Sport Performance: A Meta-Analysis. Sports Med, 47(1), 77-99.
- Carr, C. M. (2006). Sport psychology: psychologic issues and applications. Phys Med Rehabil Clin N Am, 17(3), 519-535.
- Gee, C. J. (2010). How does sport psychology actually improve athletic performance? A framework to facilitate athletes’ and coaches’ understanding. Behav Modif, 34(5), 386-402.
- Rollo, I., Carter, J. M., Close, G. L., Yangüas, J., Gomez-Diaz, A., Medina Leal, D., . . . Podlog, L. (2021). Role of sports psychology and sports nutrition in return to play from musculoskeletal injuries in professional soccer: an interdisciplinary approach. Eur J Sport Sci, 21(7), 1054-1063.
- Singer, R. N. (1981). Sports Psychology: Waves of the Future. Phys Sportsmed, 9(3), 153-156.