Knee Archives - Opus Biological
Regenerative Medicine Explained

Regenerative Medicine Explained

The term stem cell therapy often sparks curiosity, and confusion. In the UK, regenerative medicine is carefully regulated, yet rapidly advancing. At Opus, our consultants use evidence-based regenerative approaches, including mesenchymal stem cell (MSC) therapy, to support patients with mild to moderate joint degeneration.

The aim isn’t to replace surgery, nor to promise miracle cures. It is to preserve movement, comfort and quality of life for as long as possible. Here’s what the science says:

Regenerative medicine refers to treatments designed to support the body’s own repair mechanisms. Rather than masking pain or simply reducing inflammation, regenerative approaches aim to influence the biological environment within a joint or soft tissue structure.

In orthopaedics and sports medicine, this typically focuses on:

  • Cartilage degeneration
  • Early osteoarthritis
  • Tendon pathology
  • Ligament injury
  • Chronic joint pain

The goal is not instant regeneration of “new” cartilage, but optimisation of the joint environment, reducing inflammation, supporting tissue signalling and potentially slowing degenerative progression.

Stem Cell Therapy in the UK: What’s Allowed?

When discussing stem cell therapy in the UK, clarity is essential.

The UK has strict regulatory frameworks governing the use of advanced therapies. Treatments must comply with Medicines and Healthcare products Regulatory Agency (MHRA) guidance and be delivered within appropriate clinical governance structures.

At Opus, regenerative treatments are:

  • Consultant-led

  • Evidence-informed

  • Carefully selected for suitable candidates

  • Used as part of a wider performance and rehabilitation plan

We do not present stem cell therapy as a substitute for joint replacement where surgery is clearly indicated. Instead, it may be considered for patients with mild to moderate degeneration who wish to explore conservative, biologically driven options.

What Are Mesenchymal Stem Cells (MSCs)?

Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into bone, cartilage and other connective tissues. More importantly in clinical practice, they are known for their signalling properties.

In simple terms, MSCs act less like “builders” and more like “orchestrators.” They influence the inflammatory environment within tissues and may help modulate immune responses, potentially improving pain and function in certain patients.

Interest in mesenchymal stem cell treatment in London has grown significantly over the past decade, particularly among active individuals seeking to delay surgical intervention or manage persistent joint pain.

However, it is important to understand that outcomes vary. Evidence continues to evolve, and patient selection is critical.

Who Might Be Suitable?

Within a structured joint pain treatment pathway, regenerative medicine may be discussed for individuals who:

  • Have mild to moderate osteoarthritis
  • Experience persistent joint pain despite physiotherapy 
  • Wish to delay surgical intervention
  • Remain active and motivated to engage in rehabilitation
  • Have realistic expectations about outcomes

It is not suitable for everyone. Severe joint collapse, advanced bone-on-bone arthritis or mechanical instability may require surgical management.

At Opus, regenerative therapy is never offered in isolation. It sits within a comprehensive sports medicine assessment, including imaging where appropriate, biomechanical review and structured rehabilitation planning.

How Regenerative Medicine Fits into Sports Medicine

The most important misconception about regenerative medicine is that it is a “quick fix.”

In reality, regenerative treatments are one component of a broader strategy. At Opus, this includes:

  • Detailed sports medicine consultation

  • Load management advice

  • Targeted physiotherapy

  • Strength and conditioning principles

  • Ongoing clinical review

Regenerative medicine supports the biological environment. Rehabilitation builds mechanical resilience. Both are required for meaningful improvement.

This integrated approach reflects the evolution of regenerative medicine in London, away from standalone injections, and towards medically supervised, outcome-focused pathways.

What Does the Evidence Say?

Research into MSC therapy for joint conditions is ongoing. Current evidence suggests potential benefits in:

  • Pain reduction

  • Functional improvement

  • Delayed progression in selected cases

However, it is not a guaranteed solution. High-quality, long-term randomised data is still developing. Responsible clinics must communicate both the potential and the limitations.

At Opus, transparency underpins every consultation. Patients are provided with balanced information so they can make informed decisions aligned with their goals.

The Future of Joint Longevity

As life expectancy increases and more individuals remain physically active into midlife and beyond, the demand for non-surgical joint preservation strategies will continue to grow.

Regenerative medicine represents one of the most promising areas in modern musculoskeletal care not because it replaces surgery, but because it may help extend the lifespan of native joints.

For patients seeking advanced, carefully governed stem cell therapy in the UK, consultant-led mesenchymal stem cell treatment in London, or comprehensive joint pain treatment in London, Opus provides a medically rigorous, performance-focused environment. It is about preserving movement, intelligently and responsibly, for as long as possible.

Cluster of stem cells viewed under a microscope

A New Approach to Managing Osteoarthritis: The Role of Stem Cell Therapy and Regenerative Medicine

A New Approach to Managing Osteoarthritis: The Role of Stem Cell Therapy and Regenerative Medicine

Understanding Osteoarthritis and Its Impact

Osteoarthritis (OA) is one of the most common joint conditions, affecting millions of people worldwide. It develops when the protective cartilage that cushions the joints gradually wears away, leading to pain, stiffness, and reduced mobility. Over time, the condition can significantly impact daily activities, making tasks such as walking, climbing stairs, or even getting out of bed challenging.

Traditional treatments for OA include pain relief medications, physiotherapy , steroid injections, and, in severe cases, joint replacement surgery. While these treatments help manage symptoms, they do not address the underlying cause, cartilage loss. This has led to growing interest in regenerative medicine, an emerging field focused on helping the body repair itself.

One area of regenerative medicine that has gained attention in recent years is stem cell therapy . Although this treatment is still undergoing research and development, early findings suggest it may offer a new approach to joint health by supporting tissue repair and reducing inflammation.

What Are Stem Cells?

Stem cells are special types of cells that have the potential to develop into different cell types in the body. This ability makes them important for healing and regeneration. The human body contains various types of stem cells, but mesenchymal stem cells (MSCs) are of particular interest when it comes to joint health.

MSCs can be obtained from several sources, including:

  • Bone marrow (from inside bones)
  • Adipose tissue (fat cells)
  • Umbilical cord tissue (from donated umbilical cords after birth)

Among these, umbilical cord-derived MSCs (UC-MSCs) have been widely studied for their potential role in joint repair.

How Can Stem Cells Help in Osteoarthritis?

While osteoarthritis is typically considered irreversible, ongoing research is exploring how stem cells might help slow its progression, reduce symptoms, and potentially support cartilage repair.

The Role of UC-MSCs in Joint Health

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) are being studied for their ability to:

  • Reduce inflammation in the joint – Inflammation plays a key role in osteoarthritis and contributes to pain and stiffness.
  • Support cartilage maintenance – While research is ongoing, UC-MSCs are believed to release factors that encourage cartilage cells to survive and function.
  • Improve joint lubrication – UC-MSCs may help enhance the quality of synovial fluid, the natural lubricant in joints, improving movement.
  • Modulate the immune system – Osteoarthritis has been linked to immune system activity. UC-MSCs have the potential to balance immune responses in the joint.

Research into UC-MSCs is still ongoing, and while early results are promising, more studies are needed to determine their long-term effects and optimal use.

What Does the Latest Research Say?

Over the past few years, several studies have explored the potential of umbilical cord-derived stem cells in osteoarthritis treatment. Some notable findings include:

  1. Potential for Knee Cartilage Repair
    A review published in Medicine (2025) examined the use of UC-MSCs for knee osteoarthritis. The study found that these cells may contribute to reduced pain, improved function, and potential cartilage preservation. (Liao et al., 2025).
    📄 Read More: LWW Journal
  2. Stem Cell-Based Hydrogels for Cartilage Support
    A study in ACS Biomaterials Science (2025) investigated biodegradable hydrogels combined with UC-MSCs to enhance cartilage repair. The findings suggested improved joint function and reduced inflammation. (Ghosal et al., 2025).
    📄 Read More: ACS Publications
  3. Exosome Therapy for Osteoarthritis
    Scientists are also studying exosomes—tiny particles released by UC-MSCs – which may have anti-inflammatory and regenerative effects. A study in Advanced Functional Materials (2025) showed that exosomes from UC-MSCs supported cartilage repair and joint function in osteoarthritis models. (Lv et al., 2025).
    📄 Read More: Wiley Online Library
  4. UC-MSCs and Joint Injections
    Clinical trials published in Stem Cell Research & Therapy (2025) evaluated the safety and effects of UC-MSC injections for knee OA. The study noted improvements in pain, mobility, and joint function after six months. (Lei et al., 2025).
    📄 Read More: Springer

These studies represent a growing body of research exploring how stem cells may contribute to joint health and osteoarthritis management.

Important Considerations

While the idea of regenerative treatments for osteoarthritis is exciting, there are a few important points to keep in mind:

1. Research is Ongoing

Stem cell treatments, including those using umbilical cord-derived stem cells, are still being researched. Scientists continue to investigate their effectiveness, best application methods, and long-term safety.

2. Treatments Are Not Yet Widely Approved

While some countries have introduced regenerative medicine into clinical practice, regulatory authorities such as the UK’s MHRA (Medicines and Healthcare products Regulatory Agency) are still assessing these treatments. Opus, unlike many other clinics, is the UKs only licenced and regulated provider. It is essential to stay informed and seek advice from medical professionals before considering any new treatment options.

3. Every Patient is Different

Osteoarthritis can vary widely between individuals, meaning that treatment responses may differ. What works for one person may not work in the same way for another.

4. A Holistic Approach is Best

Stem cell therapy, if proven to be effective in the future, is unlikely to be a standalone cure for osteoarthritis. It is always best considered alongside other approaches such as:

  • Maintaining a healthy weight to reduce joint strain.
  • Engaging in regular, low-impact exercise (such as swimming or cycling).
  • Using joint-friendly supplements (such as glucosamine and omega-3 fatty acids).
  • Following a balanced diet to support joint health.

 

The Future of Regenerative Medicine

Research into umbilical cord-derived stem cells for osteoarthritis is advancing rapidly, with promising early results. Scientists are also exploring combination therapies, including:

  • Stem cells with growth factors to enhance repair.
  • 3D-printed cartilage scaffolds to create personalised joint implants.
  • Gene editing to enhance stem cell performance.

As research continues, the goal is to develop treatments that not only relieve symptoms but also support the long-term health of joints.

Conclusion

Osteoarthritis remains a challenging condition, but advances in stem cell research and regenerative medicine are opening up new possibilities. While umbilical cord-derived stem cells are still being studied, they hold promise as a potential tool for reducing inflammation, supporting joint function, and promoting cartilage health.

For now, education and staying informed about scientific advancements are key. As more research emerges, individuals seeking alternative approaches to joint care will have a better understanding of the options available.

If you are considering different ways to manage osteoarthritis, always consult a healthcare professional for personalised advice.

 

References

  1. Liao, Z.K. et al. (2025). Clinical research progress of umbilical cord blood mesenchymal stem cells in knee articular cartilage repair. Medicine.
    📄 Read More
  2. Lei, J. et al. (2025). Therapeutic efficacy of intra-articular injection of UC-MSCs in knee OA. Stem Cell Research & Therapy.
    📄 Read More

 

Osteoarthritis

The Importance of Criteria-Based ACL Rehabilitation: A Structured Approach

The Importance of Criteria-Based ACL Rehabilitation: A Structured Approach

Recovering from an ACL injury can be daunting, but with the right plan, our patients can rebuild strength, regain confidence, and return to the activities they love. A structured, criteria-based approach is essential not just for recovery but for reducing re-injury risk and achieving long-term success.

Here’s the criteria based approach we use to guide our patients:

Acute Phase The focus is on reducing pain (≤3/10 on VAS), managing swelling, and restoring full knee extension. Early progress in these areas is crucial for setting the foundation for later phases. Key methods: neuromuscular stimulation, passive/active extension exercises, and gait re-education drills.

Early Rehabilitation This phase targets movement and endurance. Goals include achieving 120° of knee flexion and improving muscular control with exercises like leg presses and single-leg squats. Building strength here supports long-term stability.

Strength & Control We move into heavier strength training, focusing on 2–4 sets of 8–10 reps at 60–80% of one-rep max. Controlled jumping and landing drills (e.g., sub-maximal bilateral landings) are introduced to prepare for higher-intensity demands.

Advanced Plyometrics Single-leg plyometric training and advanced strength work dominate this phase. We aim for functional goals like an 80% limb symmetry index or 1.5× body weight on leg presses. This phase is about translating strength into power and functional movement.

Return to Sport Here, sports-specific training and multidirectional movements take priority. A safe return to play requires not only physical readiness but psychological confidence, assessed through validated tools and a multidisciplinary team (MDT) approach.

Why This Approach Works:

Recent research highlights the effectiveness of criteria-based protocols:

  • Tailored Programs: Improve outcomes and reduce re-injury rates, ensuring progress at each phase of recovery (Griffin et al., 2020; Hewett et al., 2019).
  • Strength and Neuromuscular Control: Critical for knee stability, reducing risks of compensatory injuries and re-injury (Krebs et al., 2021).
  • Psychological Readiness: Athletes report higher confidence and readiness to return to sport when mental readiness is prioritised (Fitzgerald et al., 2020).

Conclusion:

Recovering from an ACL injury isn’t just about regaining movement it’s about returning stronger and more prepared for the challenges ahead. A criteria-based approach ensures that every phase of rehabilitation has clear goals tailored to each athlete’s unique needs.

References:

  • Fitzgerald, G.K., Paterno, M.V., and Myer, G.D. (2020). Psychological readiness to return to sport after ACL reconstruction: A systematic review. Journal of Orthopaedic & Sports Physical Therapy, 50(10), pp. 558–566.
  • Griffin, L.Y., Albohm, M.J., and Arendt, E.A. (2020). Understanding and preventing noncontact anterior cruciate ligament injuries: A review of the literature. Sports Health, 12(3), pp. 240–246.
  • Hewett, T.E., Myer, G.D., and Ford, K.R. (2019). Preventing knee injuries in athletes: An evidence-based approach to training. Clinical Sports Medicine, 38(1), pp. 1–24.
  • Järvinen, T.A.H., Järvinen, T.L.N., and Kalimo, H. (2021). Rehabilitation of the anterior cruciate ligament: A review. Sports Medicine, 51(3), pp. 447–461.
  • Krebs, A., Naal, F.D., and Maffulli, N. (2021). The role of structured rehabilitation in the management of anterior cruciate ligament injury: A systematic review. British Journal of Sports Medicine, 55(12), pp. 684–690

Illustration of a physiotherapist guiding a patient through a step exercise
Importance of calf capacity

Importance of calf capacity

The Importance of Good Calf Muscle Capacity in Preventing and Rehabilitating Lower Limb Injuries

Calf muscles, primarily consisting of the gastrocnemius and soleus muscles, play a vital role in lower limb function and overall biomechanics. These muscles are essential for movements such as walking, running, and jumping, contributing to ankle stability, propulsion, and shock absorption. Strong and flexible calf muscles not only enhance athletic performance but also prevent lower limb injuries and support rehabilitation after injury. This article outlines the importance of calf muscle capacity, provides data on its impact on joint loading, and explains how to assess calf capacity in clinical settings.

The Role of Calf Muscles in Lower Limb Function

The calf muscles work as a dynamic powerhouse during movement. The gastrocnemius and soleus muscles, in conjunction with the Achilles tendon, drive plantarflexion, which is the action of pushing the foot off the ground. This movement is crucial for walking, running, and jumping, as it propels the body forward. Additionally, the calf muscles play a role in absorbing the impact forces generated when the foot strikes the ground, thus reducing stress on other structures like the knee, hip, and lower back.

By acting as shock absorbers and stabilizers, the calf muscles influence the load distribution across the entire lower limb. Proper calf function ensures that forces are dispersed evenly, preventing overloading of other structures and contributing to balanced biomechanics. When calf muscles are weak or fatigued, they fail to perform this role efficiently, leading to improper movement patterns and potentially contributing to injuries of the lower limb, such as ankle sprains, Achilles tendinopathy, anterior knee pain, and plantar fasciitis. Weak calf musculature may also exacerbate symptoms such as osteoarthritis in the foot, ankle and knee.  A study by Alshami and Alhassany (2020) 1, found that calf muscle strength was significantly reduced in the patients with knee OA compared with that in the healthy control participants. Therefore it could be a good idea to ensure that within an OA knee patient’s exercise programme, there is targeted calf strengthening.

Impact of Strong Calf Muscles on Knee Joint Loading

Strong calf muscles not only support the ankle but also significantly reduce the load on the knee joint during various activities. Research has shown that adequate calf strength can reduce knee joint loading by absorbing the ground reaction forces that occur during walking or running. The soleus muscle, in particular, is known to play a key role in reducing the stress on the knee by generating posterior shear forces at the tibia, which counteract the forward forces that tend to overwork the knee.

A 2019 study by A. Bohm, 2,  found that the soleus muscle can contribute up to 50% of the force needed to decelerate the body during walking and running, thereby offloading the knee joint considerably. Research indicates that strong calf muscles can reduce the load on the knee by up to 20-25% during activities like walking and stair climbing . This effect is critical in both preventing injuries such as patellofemoral pain syndrome and in managing conditions like osteoarthritis, where reduced joint loading can slow the progression of cartilage wear.

In individuals with weakened calf muscles, this offloading effect is diminished, forcing the knee and other structures to take on additional load, which increases the risk of injury. Athletes, in particular, benefit from strong calf muscles, as these muscles allow them to handle high-impact activities like running and jumping without overstressing the knee joint.

Testing Calf Capacity in Clinical Settings

Given the importance of calf muscle capacity in preventing and rehabilitating lower limb injuries, clinicians need reliable methods to assess both the strength and endurance of the calf muscles. Below are some of the most effective ways to test calf capacity in a clinical setting:

  • Calf-Raise Test (Repetitive Heel-Raise Test): The single-leg calf-raise test is a simple and widely used method to assess calf muscle endurance. In this test, the patient stands on one leg and performs heel raises, lifting the heel off the ground as high as possible with the number of repetitions completed before fatigue, recorded. This test evaluates both the gastrocnemius and soleus muscles, providing a measure of endurance, which is critical for injury prevention. Hebert et. Al (2017) 2, carried out a great study which generated a guide to target rep ranges for different patient groups based on age and sex.
  • Maximal Voluntary Isometric Contraction (MVIC): This test measures the maximum force a person can generate during an isometric contraction of the calf muscles. Using a dynamometer, clinicians can measure the force output when the patient pushes against resistance in a fixed position. The MVIC is a reliable method to assess the maximal strength of the calf muscles, especially useful in identifying deficits that may contribute to injury risk or delay rehabilitation.
  • Single-Leg Hop Test: This test is used to evaluate functional strength and power in the calf muscles. The patient is asked to perform a series of single-leg hops for distance or height. A significant discrepancy between the two legs indicates potential calf muscle weakness or imbalance. This test is particularly useful for athletes who need to perform explosive movements during sport, as it mimics the high-force demands placed on the calf muscles.
  • Functional Movement Assessments: Assessing how the calf muscles function during movements like squats, walking, or running is also valuable in clinical settings. Analysing gait or performing functional movement screens allows clinicians to observe whether the calf muscles are functioning optimally during dynamic activities. This type of assessment is particularly relevant for athletes and individuals recovering from injury, as it highlights any biomechanical deficiencies related to calf muscle performance.

Rehabilitation of Lower Limb Injuries: Calf Strengthening

Injury rehabilitation programs often include exercises aimed at restoring calf muscle strength, endurance, and flexibility. Isometric calf exercises can be used early in rehabilitation to improve muscle activation without placing too much strain on the injured tissue. Over time, patients progress to more dynamic exercises such as calf raises, hopping, and plyometric drills, depending on the severity of their injury and their physical goals. Green et. Al (2022) 3, break up the involvement of calf specific exercises into 4 nice stages which a patient or player should go through in order to go from day 1 to return to play. These stages are: Early loading and foundation calf and lower limb function, Loaded strengthening, loaded power, plyometrics and ballistics and finally, Locomotion.

Conclusion

Good calf muscle capacity is vital for preventing lower limb injuries and supporting effective rehabilitation. Strong and flexible calf muscles reduce the load on the knee joint by as much as 20-25%, play an essential role in stabilizing the ankle, and help prevent common injuries such as Achilles tendinopathy, plantar fasciitis, and knee injuries. Clinicians can use a variety of tests, such as the calf-raise test and MVIC, to assess calf muscle strength and endurance. By incorporating calf training and flexibility exercises into rehabilitation and prevention programs, individuals can improve their lower limb function, reduce the risk of injury, and ensure a quicker recovery following injury.

Reference List

 

  • Alshami, A.M. and Alhassany, H.A. (2020). Girth, strength, and flexibility of the calf muscle in patients with knee osteoarthritis: A case–control study. Journal of Taibah University Medical Sciences, 15(3), pp.197–202. doi:https://doi.org/10.1016/j.jtumed.2020.04.002.
  • Bohm S, Mersmann F, Santuz A, Arampatzis A.. 2019. The force–length–velocity potential of the human soleus muscle is related to the energetic cost of running. Proc. R. Soc. B Biol. Sci. 286, 20192560 ( 10.1098/rspb.2019.2560)
  • Hébert-Losier, K., Wessman, C., Alricsson, M. and Svantesson, U. (2017). Updated reliability and normative values for the standing heel-rise test in healthy adults. Physiotherapy, 103(4), pp.446–452. doi:https://doi.org/10.1016/j.physio.2017.03.002.
  • Green, B., McClelland, J.A., Semciw, A.I. et al. The Assessment, Management and Prevention of Calf Muscle Strain Injuries: A Qualitative Study of the Practices and Perspectives of 20 Expert Sports Clinicians. Sports Med – Open 8, 10 (2022). https://doi.org/10.1186/s40798-021-00364-0
Runner in shorts and trainers on an outdoor athletics track
Musculoskeletal Disorders in Menopausal Women

Musculoskeletal Disorders in Menopausal Women

Menopause causes a deficiency in oestrogen which can result in an increased risk of cardiovascular disease, cancer, cognitive decline, chronic obstructive pulmonary disease, diabetes, metabolic syndrome, depression, sleep disturbances, vasomotor symptoms, migraines and musculoskeletal disorders. The most common musculoskeletal disorders in menopausal women are osteoporosis, sarcopenia and osteoarthritis (Dijk et.al, 2015).

During the menopausal transition, there is an increase of muscle degeneration which can progress to sarcopenia. The decrease in oestrogen and testosterone leads to ‘neuromuscular junction insufficiency, myofiber loss, mitochondrial dysfunction’ (Buckinx and Aubertin-Leheudre, 2022) and reduced muscle regeneration.  These physiological changes increase fat deposits in muscle and increase the difficulty in achieving hypertrophy and maintaining muscle mass (Buckinx and Aubertin-Leheudre, 2022). The prevalence of osteoporosis in menopausal women is extremely high, as more than two million women have osteoporosis in England and Wales. After the menopause, prevalence rises with age from approximately 2% at 50 years to more than 25% at 80 years’ (Peto and Allaby, 2013) This is likely due to the osteoclastic resorption activity increases and the osteoblastic activity decreases, resulting in more bone being absorbed than being formed (Ji and Yu, 2015).

There is an abundance of research illustrating the impact menopause has on osteoporosis and sarcopenia, however there is limited evidence on the impact of osteoarthritis on musculoskeletal disorders (Watt, 2018). However, Richmond et. al found oestrogen receptors in articular cartilage which potentially demonstrates a relationship between oestrogen and articular cartilage health. Zhang et al. discovered that oestrogen has a positive impact on cartilage. These studies illustrate there is relationship between oestrogen and cartilage however unable to identify an explanation for the clinical significance (Hame and Alexander, 2013). Lower back pain (LBP) is also more common in postmenopausal women than men who are within the same age group. This is most likely due to oestrogen deficiency causing postmenopausal women to have increased prevalence of disc degeneration; therefore, resulting in increased risk of spondylolisthesis and facet joint osteoarthritis. Also due to higher rates of osteoporosis in postmenopausal women, osteoporosis related spine fracture, especially at thoracolumbar junction, can cause LBP (Wang, 2017).

There is a wealth of research showing the importance of menopausal women participating in exercise to reduce the risk of musculoskeletal disorders and prevent the worsening of symptoms (Grindler et. al 2015). For example, Mendoza et. al found that exercise reduces osteoarticular pain in postmenopausal women with fibromyalgia or breast cancer (Mendoza et. al, 2016). Research suggests a combination of high impact exercises and weight training is optimal to increase muscle mass and bone density, alongside medical intervention such as hormone replacement therapy and supplementation. Metcalfe et .al found the combination of adding calcium, hormone replacement therapy and weight bearing movement increases bone mass density and muscle strength for post- menopausal women. The weight bearing movements included stair climber or stepping alongside resistance training and balance exercises to reduce the risk of osteoporosis, sarcopenia and fractures (Metcalfe et. al, 2001). Hettchen et. al 2021 also demonstrated the positive impact exercise has on early postmenopausal women with osteopenia or osteoporosis and disorders related to menopausal transition. The exercise regime included a combination of high intensity training, jumping sequences and velocity resistance training (Hettchen et. al 2021).  The evidence illustrates the importance of physical activity for menopausal women, however more research is required to see the impact menopause has on other musculoskeletal disorders.

Reference List

 

Woman jogging outdoors in a teal top
Platelet rich plasma: The scientific evidence

Platelet rich plasma: The scientific evidence

Physiotherapist stretching a patient's leg on a treatment couch
We have already had a look at how platelet rich plasma (PRP) works (if you haven’t had a chance to read this yet, you can find it here), but now we are going to dive more deeply into the scientific evidence behind this treatment.
Randomised controlled trials (RCTs) are the gold standard study for determining if one treatment offers superior benefits over another. In these trials, patients are randomly assigned to either receive the treatment of interest or an alternative treatment, usually the standard of care or a placebo. Moreover, the patients are ‘blind’ to what treatment they are receiving. Here, we are going to look at two RCTs that investigated the use of PRP to treat knee osteoarthritis and chronic tennis elbow.

Knee osteoarthritis

A study by Bansal et al. (2021) investigated the optimal dose and concentration of therapeutic PRP required to achieve the desired physiologic efficacy. One hundred and fifty patients were enrolled in this trial, with then being randomised to either receive PRP or hyaluronic acid for their knee osteoarthritis.
The results revealed a significant improvement in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), International Knee Documentation Committee (IKDC) score*, and six-minute pain free walking distance. Besides external improvements, this trial also noted a significant decline in IL-6 and TNF-a levels in the PRP group when compared to the hyaluronic acid group at six months, both of which assist in mediating an inflammatory state (Bansal et al., 2021). If you would like to read more about the role of these cytokines in osteoarthritis, we have an additional blog post discussing just that.
Collectively, this trial, along with several others, demonstrate the efficacy of PRP, specifically with an absolute count of ten billion platelets, in achieving a long sustained chondroprotective effective in arthritis.
*The WOMAC represents an osteoarthritis index and measures a patients’ physical function, pain, and stiffness over a 48 hour period. The IKDC, on the other hand, gives an indication of a patients’ condition, containing questions on knee symptoms, overall function, and sports activities. The scoring system ranges from zero to one hundred, with zero representing the lowest level of function and the highest level of symptoms.

Chronic tennis elbow

A study by Mishra et al. (2014) evaluated the clinical value of tendon needling with PRP in 230 patients with chronic tennis elbow compared with an active control group. Patient outcomes were followed for up to 24 weeks, with the findings revealing several beneficial results at this mark. In those treated with PRP, a significant improvement of 71.5% was observed in their pain scores. Moreover, the percentage of patients reporting significant elbow tenderness notably decreased over this time. This demonstrates the clinical efficacy of PRP in the treatment of chronic tennis elbow on a larger scale (Mishra et al., 2014).

References

Bansal, H., Leon, J., Pont, J. L., Wilson, D. A., Bansal, A., Agarwal, D. & Preoteasa, I. 2021. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy. Scientific Reports, 11, 3971. Mishra, A. K., Skrepnik, N. V., Edwards, S. G., Jones, G. L., Sampson, S., Vermillion, D. A., Ramsey, M. L., Karli, D. C. & Rettig, A. C. 2014. Efficacy of platelet-rich plasma for chronic tennis elbow: a double-blind, prospective, multicenter, randomized controlled trial of 230 patients. Am J Sports Med, 42, 463-71.